An Efficient One-Pot Synthesis of 6,9-Dihydrofuro[3,2-f]Quinoline-8-Carbonitrile Derivatives under Catalyst-Free Conditions

Abstract

A new series of 6,9-dihydrofuro[3,2-f]quinoline-8-carbonitrile derivatives were prepared, via one-pot reaction of ethyl 5-aminobenzofuran-2-carboxylate, aromatic aldehydes and 3-oxo-3-phenylpropanenitrile in ethanol as a solvent at reflux. The advantages of this protocol include mild reaction conditions, easy purification, high yields, and catalyst-free approach. IR, ¹H NMR, ¹³C NMR and HRMS spectras were used to identify the structures of all the synthesized compounds.

Graphical Abstract

Keywords:

• One-pot reaction
• furo[3,2-f]quinoline
• 5-aminobenzofuran-2-carboxylate

Acknowledgement

We are grateful to the Natural Science Foundation for Colleges and Universities of Jiangsu Province (18KJB150024), Science and Technology Development Fund of Kangda College of Nanjing Medical University (KD2020KYJJZD072) and Innovation training program projects for the students of Kangda College of Nanjing Medical University for financial support.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Scheme 1. The model reaction of 1, 2a, and 3.