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Polycyclic Aromatic Compounds Volume 42, 2022 - Issue 10
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Research Articles

Synthesis of Some Novel Indoline-2,3-Dione Derivatives and the Influence of Gamma Irradiation on Their Biological Activities

Eman Mansoura Organic Chemistry Department, Faculty of Women’s for Arts, Science and Education, Ain Shams University, Cairo, EgyptCorrespondence[email protected]
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,
H. A. Taherb Atomic Energy Authority. Department of Drug Radiation Research, National Center for Radiation Research and Technology, Cairo, EgyptView further author information
,
A. F. El-Farargyc Chemistry Department, Faculty of Science, Zagazig University, Zagazig, EgyptView further author information
&
Safaa I. Elewaa Organic Chemistry Department, Faculty of Women’s for Arts, Science and Education, Ain Shams University, Cairo, EgyptView further author information
Pages 6846-6860 | Received 23 Aug 2021, Accepted 29 Sep 2021, Published online: 23 Oct 2021
 
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Abstract

2-(2-oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide (4) was synthesized by reaction of 3-hydrazonoindolin-2-one (3) with phenyl isothiocyanate in DMF in presence of potassium hydroxide. Thus, treatment of 4 with the appropriate halo ketones, hydrazonoyl halides, and benzylidene malononitriles afforded thiazolidin-4-one, and thiadiazole derivatives. Moreover, structures of the newly synthesized compounds were elucidated as based of elemental analysis and spectral data. Also, the influence of gamma irradiation on the biological activities of the new compounds was evaluated.

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This study was supported by Faculty of Women’s for Arts, Science and Education, Ain Shams University.

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