Synthesis of Pyrimidinyl Benzazolyl Urea Derivatives as Antimicrobial and Antioxidant Agents

Abstract

A library of pyrimidinyl benzazolyl urea derivatives were synthesized from pyrimidine-2- amine and methyl benzazolylcarbamate in the presence of potassium tert-butoxide in DMF. The compounds with benzothiazolyl and benzimidazolyl moieties having chloro and nitro substituents on the aromatic ring exhibited prominent antibacterial activity against Bacillus subtilus. Nitro substituted pyrimidinyl benzothiazolyl urea and pyrimidinyl benzimidazolyl urea displayed prominent antifungal activity against Asperigellus niger. The compounds with benzoxazole moiety showed greater radical scavenging activity than those with benzothiazole and benzimidazole units.

Keywords:

• Pyrimidinyl benzazolyl urea
• potassium tert-butoxide
• antibacterial activity
• antifungal activity
• antioxidant activity

Acknowledgement

The authors are grateful to Council of Scientific and Industrial Research (CSIR), New Delhi for financial assistance under major research project.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

The authors are grateful to Council of Scientific and Industrial Research (CSIR), New Delhi for financial assistance under major research project.