One Pot Three Component Synthesis of Substituted 3,4,6,7-Tetrahydro-3,3,6,6-Tetramethyl-9,10-Diphenylacridine-1,8(2H,5H,9H,10H)-Diones Catalyzed by Mesostrucrted In₂O₃-SiO₂

Abstract

A convenient, one pot synthesis of heterocyclic nucleous acridine derivative compound achieved those are having very much attention in medicinal chemistry because of their extensive application in biology. The mixture of dimedone, substituted benzaldehyde, and aniline catalyzed by efficient In₂O₃-SiO₂ heterogeneous reusable catalyst in ethanol to obtain the desired acridine derivatives with good yield. The hydrothermal method used to synthesize mesostructured In₂O₃-SiO₂ catalytic material. This catalytic material were characterized by using X-ray diffraction spectroscopy, scanning electron microscopy, energy dispersive spectroscopy, Fourier transform infrared spectroscopy, temperature-programmed desorption, and Brunauer–Emmett–Teller. Our synthetic strategy features high yield, simple work up procedure, nontoxic, clean, and easy recovery and reusability of the catalytic system.

Keywords:

• Mesostructured
• In₂O₃-SiO₂
• hydrothermal method
• acridine

Acknowledgments

We are grateful to the Head, Department of Chemistry, Dr. B.A.M. University, Aurangabad 431004 (MS), India for providing the laboratory facility, and to the STIC Cochin, SAIF Chandigarh, and IIT Bombay for characterization facilities. Author also thankful to the Principal, Mahant Jamnadas Maharaj Arts, Commerce and Science College, Karanjali.

Disclosure statement

No potential conflict of interest was reported by the authors.