345
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

A Simple and Efficient Ligand-Free Copper-Catalyzed C-N Bond Formation of Aryl (Hetero) Halides and N-Heteroaryl Amines

, , &
Pages 665-673 | Received 05 Oct 2021, Accepted 04 Dec 2021, Published online: 27 Dec 2021
 

Abstract

In this protocol, we report a simple, inexpensive, and user-friendly conventional method for C-N cross coupling between aryl/heteroaryl halides and hetero aryl amines using copper iodide as a catalyst in DMSO as a solvent to prepare pyrimidines and pyrazines derivatives. The reaction conditions were optimized by screening in various copper catalysts and bases. The substrate scope of the reaction was also carried out to prepare novel functionalized N-arylated compounds in good yields.

Graphical Abstract

Acknowledgment

Dr. Krishnaji acknowledges CHRIST (Deemed to be University), Bangalore for funding Major Research Project (MRP # MRPDSC-1723).

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Dr. Krishnaji acknowledges CHRIST (Deemed to be University), Bangalore for funding Major Research Project (MRP # MRPDSC-1723).

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,492.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.