Microwave-Assisted Chemistry: New Synthetic Application for the Rapid Construction of 1H-Pyrazolo[1,2-b]Phthalazine-5,10-Dione Derivatives in Diisopropyl Ethyl Ammonium Acetate

Abstract

In the frame of research that examines the use of task-specific ionic liquids (ILs) for developing green methodologies toward bioactive substituted 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives via one-pot condensation of aldehydes, malononitrile and phthalhydrazide presence of Diisopropyl Ethyl Ammonium Acetate (DIPEAc-IL) as catalyst under conventional reflux as well as microwave irradiation condition. providing the desired product in very satisfactory yields (up to 94%) and high purity after simple workup. The task-specific ILs were recycled and reused four times without a noticeable decrease in their catalytic activity. Mild conditions with excellent conversions and simple product isolation procedures are noteworthy advantages of this method. The recyclability of the ionic liquid makes this protocol environmentally benign.

Graphical Abstract

Keywords:

• Multicomponent reaction
• 1H-Pyrazolo[1,2-b]phthalazine-5,10-diones
• DIPEAc
• Ionic liquid
• Microwave Assisted Synthesis

Acknowledgments

The author C.K.J. is very much thankful to the Council for Scientific and Industrial Research (CSIR), New Delhi, for the award senior research fellowship. The author is also grateful to the Authority of Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad- 431004, India, for providing laboratory facility. We are also thankful to SAIF, CSIR-CDRI, Lucknow, and BITS-Pilani, India. For providing spectral analysis data.

Disclosure statement

The authors declare no competing financial interest.

Author contributions

The manuscript was written through the contributions of all authors. All authors have approved the final version of the manuscript.

Additional information

Funding

This work was funded by Council of Scientific and Industrial Research.