Abstract
In this study, the surface of magnetic nano-Fe3O4 NPs was functionalized with melamine-imidazole groups to synthesize a novel heterogeneous support (Fe3O4@SiO2@Si(CH2)3NH@CC@Im). Then, cobalt (II) acetate was added to the prepared support and, finally we used Fe3O4@SiO2@Si(CH2)3NH@CC@Im@Co in order to construct 2-amino-3-cyanopyridines from the reaction of aldehydes, acetophenones, malononitrile and ammonium acetate. Synthesis of 2-amino-3-cyanopyridines was achieved in one pot operation by utilizing a simple set of readily available starting materials in excellent product yields with short reaction time. Furthermore, the prepared green heterogeneous catalyst can be recycled and recovered six times.
Acknowledgments
The authors would like to thank Bu-Ali Sina University, Center of Excellence Developmental of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS) for financial supporting of this research.
Disclosure statement
No potential conflict of interest was reported by the authors.