Characterization and Molecular Docking Analysis for the Supramolecular Interaction of Lidocaine with β-Cyclodextrin

Abstract

In the present work, Lidocaine: β-Cyclodextrin (LDC:β-CD) complex is formed and confirmed through analytical methods. The absorption and fluorescence maxima of the complex is shifted toward the blue region with the increasing concentration of β-CD. The FT-IR study predicts the entrapment of the aromatic part into the cavity of the host, as the stretching frequencies of those groups are higher than the frequencies of the pure LDC and its physically mixed (PM and KM) products. A best model is arrived through the molecular docking study with the help of Patch-Dock server for the complex formation. The cytotoxic activity of the complex is improved due to the encapsulation process and it is active toward the cancer cells even though, the pure LDC is inert to the cell line in nature.

Keywords:

• Lidocaine
• β-Cyclodextrin
• solid complex
• FT-IR
• docking
• in-vitro cytotoxicity