Production of Pyrimidobenzazepine Derivatives and Reduction of Organic Pollutant Using Ag/Fe₃O₄/TiO₂/CuO@MWCNTs MNCs

Abstract

The Petasites hybridus rhizome water extract as green media was used for the preparation of the Ag/Fe₃O₄/TiO₂/CuO@MWCNTs magnetic nanocomposites and its activity was evaluated by using in the one-pot multicomponent reaction of isoquinoline, α-haloketones, 2-amino benzoic acids, diethyl carbonate, electron deficient acetylenic compounds, ammonium acetate, and tert-butyl isocyanide in water at room temperature for the production of novel derivatives of pyrimidobenzazepines in excellent yields. Moreover, reduction of organic pollutants such 4-nitrophenol was performed by synthesized Ag/Fe₃O₄/TiO₂/CuO@MWCNTs in water at room temperature. The outcomes showed this catalyst was decreased organic pollutants in few seconds. Because of having azepine moiety, the synthesized compounds show good antioxidant activity. These synthesized compounds also displayed antimicrobial activity by using the disk diffusion procedure and two Gram-positive and Gram-negative bacteria. The employed process for production of benzazepines has some benefits such as short time of reactions, excellent efficiency of product, easy separation of catalyst and products.

Graphical Abstract

Highlights

• Green chemistry is the use of a set of principles to reduce or eliminate the use or generation of unsafe materials in the design, fabrication, and applications of chemical products. Among solvents, water is a green solvents and very suitable for performing organic reaction.

• The present procedure avoids the use of toxic solvent.

• Heterocyclic compounds hold a prominent position in medicinal chemistry owing to their wide spectrum of biological activities such as antimalarial, antimicrobial, antitumor, anticancer, antidepressant, antiviral, antidiabetic, anti-infammatory, and anti-HIV.

Keywords:

• Ag/Fe₃O₄/TiO₂/CuO@MWCNTs
• pyrimidobenzazepines
• multi-component reaction
• alkyl bromide
• 4-nitrophenol

Disclosure statement

No potential conflict of interest was reported by the author(s).