Synthetic Utility of Bis-Aminomercapto[1,2,4] Triazoles in the Preparation of Bis- Fused Triazoles and Macrocycles

Abstract

The current review presents recent progress in the synthetic utility of bis-(4-amino-5-mercapto[1,2,4] triazoles) as building blocks for a diverse range of bis-fused [1,2,4]triazoles such as; bis-(triazolo-thiadiazoles), bis(triazolo-thiadiazines), bis(triazolo-thiadiazepines), and polymeric materials with pharmacological interest. Also, synthesis of macrocycles, containing [1,2,4]triazole subunits were demonstrated. All of these topics are drawn in this review during the period from 2000 to February 2022.

Keywords:

• Triazoles
• bis-triazoles
• bis-azolotriazoles
• bis-triazoloazines
• macrocycles

Disclosure statement

The authors declare no conflict of interest, financial or otherwise.