Ionic Liquid [(EMIM)Ac] Catalyzed Green and Efficient Synthesis of Pyrano[2,3-c]Pyrazole Derivatives

Abstract

A Green, efficient and clean route for synthesis of biologically potent pyrano[2,3-c]pyrazole derivatives has been developed in excellent yield, by using biodegradable ionic liquid 1-ethyl 3-methyl imidazolium acetate [(EMIM)Ac)] as a green catalyst via one-pot four-component condensation reaction of ethyl-acetoacetate, hydrazine-hydrate, malononitrile and carbonyl compounds at reflux condition in ethanol. The striking features of the protocol are a cleaner reaction profile, mild experimental procedure, applicable to extensive range of substrates and short reaction time.

Graphical Abstract

Keywords:

• Pyrano[2,3-c] pyrazoles
• biodegradable ionic liquid
• green Synthesis
• Condensation reaction
• cleaner reaction profile

Acknowledgements

Authors are thankful to the Principal Deogiri College, Aurangabad and Head, Department of Chemistry, Deogiri College, Aurangabad for providing research facility; and authors are also thankful to sophisticated analytical instrumentation facility (SAIF), Chandigarh Panjab for providing characterization facility.

Disclosure statement

No potential conflict of interest was reported by the author(s).