Cs₂CO₃-Promoted [3 + 2] Cyclization of Chalcone and N-Tosylhydrazone

Abstract

Cs₂CO₃-promoted [3 + 2] cyclization of chalcone and N-tosylhydrazones has been developed, a series of novel (4,5-diaryl-1H-pyrazol-3-yl)(aryl)methanone derivatives were synthesized with a wide range of substrates, good tolerance of functional groups and by a one-pot three-component reaction of chalcone, aryl formaldehyde, and TsNHNH₂. In addition, the gram-scale synthesis of the product and further transformations were also investigated.

Keywords:

• Chalcone
• cyclization
• N-tosylhydrazone

Acknowledgements

We also thank Jixing Zhao of the Analysis and Testing Center of Shihezi University for the help with data analysis.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

We gratefully acknowledge the financial support of this work by the National Natural Science Foundation of China (No. 22162022).