Q-Tube Assisted Green Synthesis of Bis(Azoles) and Bis(Azines) Linked to Arene Unit

Abstract

We reported herein efficient green procedures for the synthesis of arene-linked bis(azoles) and bis(azines) using bis(enaminone) as a key intermediate. For this purpose, bis(enaminone) were reacted with different nucleophiles under a pressurized reaction “Q-tube system” to afford the target bis(azoles) and bis(azines). The structures of the target compounds were confirmed via considering their elemental analyses as well as their spectral data. The used protocol shows a beneficial effect on the reaction time and yields compared to conventional conditions.

Keywords:

• Q-tube reactor
• green chemistry
• bis(enaminone)
• bis(azoles)
• bis(azines)

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors extend their appreciation to the Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia, for funding this research work through the project number MoE-IF-G-20-04.