Abstract
Various pyrimidine derivatives were synthesized via one-pot three-component condensation of aromatic aldehydes, malononitrile, and multiple amines using 1,1'-(butane-1,4-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) hydroxide as a basic ionic liquid catalyst under solvent-free conditions. The advantages of this method are the simplicity of the procedure, short reaction times, high yields, no-column chromatographic separation, commercial availability of the preliminary materials, and reusability of the catalyst.
Acknowledgments
The aid of the Guilan University Research Council for doing this work is gratefully acknowledged.
Disclosure statement
No potential conflict of interest was reported by the author(s).