Abstract
In our research, we produced some novel porphyrin derivatives 4a–g in high yields. We also synthesized and characterized some of their metalloporphyrin complexes 5–11. The structures of these novel porphyrins were assured by spectroscopic techniques. The geometric structure and magnetic properties of metallo-porphyrins 5–11 have also been studied. Antiviral and antitumor activities were estimated and the structures activity relationships were accomplished. The Porphyrin derivatives 4g, 4f, 9, 10 and 11 displayed strong antiviral activity for HSV-1 compared to Aphidicoline as reference. While derivatives 4g and 6 exhibited very strong activity against HIV-1. Porphyrin derivatives 4g, 6, 9, and 10, in general, displayed strong activity against all the tested human cell lines.
Acknowledgement
The authors would like to acknowledge the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant code: 22UQU4320545DSR26. The authors would like to extend their sincere appreciation to Taif University Researchers Supporting Project number (TURSP-2020/312), Taif University, Taif, Saudi Arabia.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Correction Statement
This article has been corrected with minor changes. These changes do not impact the academic content of the article.