Synthesis and Application of Novel Magnetic Glycoluril Tetrakis(Methylene Phosphorous Acid) as a Nano Biological Catalyst for the Preparation of Nicotinonitriles via a Cooperative Vinylogous Anomeric-Based Oxidation

Abstract

Herein, we synthesized biological magnetic glycoluril tetrakis(methylene phosphorous acid) as a new heterogeneous nano-catalyst. The magnetic nano-catalyst Fe₃O₄@GTMPA was used for the synthesis of diphenyl nicotinonitrile derivatives by multi-component reaction of wide spread aldehydes, acetophenones, ammonium acetate, and 3-(1H-indol-3-yl)-3-oxopropanenitrile in the solvent-free conditions at 110 °C. The final step of reaction mechanism was preceded via a cooperative vinylogous anomeric-based oxidation (CVABO) as green and convenient approach.

Keywords:

• Anomeric effect
• anomeric-based oxidation
• biological catalyst
• diphenyl nicotinonitrile
• Fe₃O₄@GTMPA
• Glycoluril tetrakis(methylene phosphorous acid)
• nano-magnetic catalyst

Acknowledgments

We thank Bu-Ali Sina University and Iran National Science Foundation (INSF) (98001912) for financial support to our research group.

Author contributions

B.D. and H.S.; methodology, validation, investigation. M.Z. and Y.G.; investigation and writing the original draft. M.A.Z.; supervision, resources, project administration, funding acquisition, conceptualization, writing-review.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by Bu-Ali Sina University and Iran National Science Foundation (INSF) [98001912].