Abstract
A new library of bis-thiazol-1,2,4-triazinehybrids having 1,3,4-oxadiazoles (10a–j) has been designed and synthesized. They were examined for their preliminary anticancer properties against four selected human cancer cell lines including SiHa (cervix), A549 (lung), MCF-7 (breast) and Colo-205 (colon) by using of MTT method and etoposide selected as a positive control. Most of the compounds displayed remarkable anticancer activities. Amongst, the five compounds 10a, 10b, 10c, 10d, and 10e demonstrated the most promising activity. Predominantly, compounds 10a and 10e possessed a higher potent inhibitory effect toward three cell lines.
Acknowledgment
The authors are thankful to Department of Chemistry, Koneru Lakshmaiah Education Foundation and Laurus Labs Limitedfor constant encouragement in providing laboratory facilities and analytical data.
Disclosure statement
No potential conflict of interest was reported by the author(s).