Synthesis of (E)-2-(Chloro (Phenyl) Methylene)-1-(6-Chloroquinoxalin-2-yl) Hydrazine Derivatives by Reusable Fe₃O₄ Nano Powder at Room Temperature

Abstract

A multicomponent reaction (MCR) for the synthesis of five novel N'-(6-chloroquinoxalin-2-yl) benzohydrazide derivatives in excellent yields at room temperature have been achieved via a reaction between 1-(6-chloroquinoxalin-2-yl) hydrazine was added 4-chloroethyl benzoyl chloride followed by the addition of Fe₃O₄ nanoparticles. This was applied as an efficient and recoverable nanocatalyst for the one‐pot synthesis of hydrazine Derivatives. The catalyst was magnetically recovered and reused for 4 consecutive cycles without significant loss of its activity and selectivity. Fe₃O₄ Nano catalyst was prepared by the co-precipitation method and characterized by X-ray diffraction (XRD), FT-IR, TEM, VSM, and analyses. This study presents an efficient multicomponent protocol, which provides several advantages, such as short reaction times, high yields, and easy working up this work.

Keywords:

• Fe₃O₄ nanoparticles
• room temperature
• synthesis
• multicomponent reaction
• hydrazine Derivatives

Acknowledgments

The authors gratefully acknowledge financial support from the Research Council of the Islamic Azad University of Yazd.

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Funding

This work was supported by the Research Council of the Islamic Azad University of Yazd.