Synthesis and Anti-Tubercular Screening of 8-Benzyloxy-5-[2-(Substituted-Phenyl)-Thiazol-4-yl]-1H-Quinolin-2-One Derivatives

Abstract

Novel 8-Benzyloxy-5-[2-(substituted-phenyl)-thiazol-4-yl]-1H-quinolin-2-one derivatives are synthesized by the cyclocondensation of substituted thiobenzamide and in-situ generated 8-benzyloxy-5-(2-bromo-acetyl)-1H-quinolin-2-one in the ethanol using simple one-pot multicomponent protocol under catalyst-free reaction conditions. All the products were screened for anti-tuberculosis (TB) activity against Mycobacterium tuberculosis H₃₇Rv stains using L. J. medium conventional method and Compound 4h show good and Compound 4a, 4c, 4e, 4g, 4i, and 4j are also showing significant activity against M. tuberculosis.

Keywords:

• One pot
• thiobenzamide
• thiazole
• quinoline
• catalyst free
• Mycobacterium tuberculosis

Acknowledgments

Authors are thankful to Principal, Maulana Azad College and research center, Aurangabad for providing library and laboratory facilities for this work and also to micro care laboratory for anti-tubercular activity.

Disclosure statement

No potential conflict of interest was reported by the author(s).