Facile Synthesis and Antioxidant Activity Screening of Some Novel 3-Substituted Indole Derivatives

Abstract

The 2-cyano-3-(indol-3-yl)acryloyl chloride, a building block synthon prepared in good yield, was utilized for the synthesis of various indolylacrylamide and indole-based heterocycles. Thus, the aforementioned acid chloride was allowed to react with various oxygen, sulfur, and nitrogen nucleophiles, in addition to mono- and bidentate nucleophiles. The pyrazolidine derivatives were produced on interactions with phenylhydrazine and 2-cyanoethanohydrazide. The antioxidant activity of the synthesized compounds was assessed using the phosphomolybdenum technique and ascorbic acid as a standard. The findings displayed that indolyl-based azine, pyrazolidine, cyanoacetamide, and benzodiazepine derivatives were the most active antioxidants.

Keywords:

• Indole
• chromene
• quinoline
• reactivity
• antioxidant

Acknowledgments

The authors thank Dr. MA Ghareeb, Theodor Bilharz Research Institute, Giza, Egypt, for making the antioxidant activity evaluation.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research received no funding.