Green Synthesis of New Derivatives of Pyrrolopyrimidine by Employing Cu@KF/Clinoptilolite NPs: Study of Antioxidant Activity

Abstract

In order to create Pyrrolo pyrimidine derivatives, multicomponent reactions involving butanoates, aldehydes, guanidine, activated acetylenic compounds, and ethyl bromopyruvate were carried out in water at room temperature with catalytic amounts of Cu@KF/CP NPs as a high-performance catalyst. Additionally, experiments involving the reducing power of ferric ions and radical trapping by DPPH were conducted to investigate the antioxidant capacity. As a result, the produced compounds exhibit excellent DPPH radical trapping and good ferric ion reduction capacity. The current method offers advantages including good reaction yield, green media, and simple product and catalyst separation.

HIGHLIGHTS

• The pyrimidine ring is an aza-aromatic scaffold that can be found in many molecules of biological or pharmaceutical interest.

• Multicomponent reactions (MCRs) are a more interesting type of reaction due to mixing three or more reactants in one-pot and generating one product. They are also more economically useful and environmentally secure than multi-step methods.

• Carrying out the synthesis of organic compounds in water media is very interesting because water is a cheap solvent more readily available in large amounts.

Graphical abstract

Keywords:

• Cu@KF/CP NPs
• ability of oxidation
• pyrimidine
• DPPH radical trapping
• guanidine

Disclosure statement

No potential conflict of interest was reported by the author(s).