Abstract
Heterocyclic chemistry is one of the emerging branches of organic chemistry due to its growing attention in pharmacology. Piperazine is a dinitrogen-containing heterocycle that spans many applications, including anticancer, anticonvulsant, antidepressant, antimicrobial, antimalarial, antiviral, antitubercular, anti-inflammatory, activities etc. In a similar fashion, the second moiety, i.e., acetanilide, an N-phenylacetamide, also executed a large number of bioactivities, which included anticancer, antileishmanial, antipyretic, analgesic, antidiabetic, antiviral potential, etc. Both moieties have large-scale potential to show bioactivities in different aspects. When both moieties combine in a single molecule, it forms a potent biological compound. A number of precursors have been used for the synthesis of piperazine-based acetanilides. In this review, we have addressed different synthetic strategies that have been reported in the past.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.