Efficient and Facile One-Pot Multi-Component Synthesis of Betti Bases Using Baker’s Yeast for the First Time

Abstract

A green and facile synthesis of 1-(α-aminoalkyl)-2-naphthols, generally called Betti bases (BB) in the presence of Baker’s yeast (BY), acts as an efficient catalyst, and ethanol as a green solvent. In this methodology, the BY is used first time as a biocatalyst (enzyme). This protocol has some inherent advantages, such as mild reaction conditions, no environmental pollution, simple work up, no need of column chromatography, diversity of reactant and desired 1-(α-aminoalkyl)-2-naphthols (Betti bases) (4a-r) are obtained in good-to-excellent yields. This is the first report on Baker’s yeast-catalyzed (BYC) synthesis for BB. This present bio-catalytical route for synthesizing BB in the presence of biocatalysts like BY is anticipated to open a gateway to synthesized complexed biological active molecules counting BB.

Graphical Abstract

HIGHLIGHTS

• A green and facile synthesis of amino alkyl naphthols (4a-r) by using Baker’s yeast as efficient catalyst and ethanol as green solvent.

• The Baker’s Yeast is used first time as biocatalyst for the multi component Betti Reaction

• The advantages of the present methods are mild reaction conditions, no environmental pollution, diversity of reactant, simple work up, no coloumn chromatography and good-to-excellent yield of desired Betti bases (4a-r).

• The reaction is totally carried out under envirnmentally friendly condition by using green solvent EtOH.

• It is anticipated that this present bio-catalytical route for the s thesis of Betti bases by using Baker’s Yeast as catalyst will open a new gateway to synthesized complexed biological active molecules counting Betti bases.

Keywords:

• Baker’s yeast
• green synthesis
• multi-component reaction
• betti reaction
• 1-(α-aminoalkyl)-2-naphthols

Acknowledgement

The authors are thankful to the Dean School of Sciences, Maulana Azad National Urdu University (MANUU), Hyderabad 500032, Telangana, India, for encouraging the research activities and providing the basic facilities for this research work.

Authors’ contributions

The author’s contribution in the above carried out study and manuscript is as follows.

Ms. Samreen Kauser is a research scholar and the present work is the part of her research work. She is involved in the designing, experimental work and drafting of manuscript. Dr. Qasim Ullah is supervisor of Ms. Samreen Kauser and involved in this present finalizing the work designing, manuscript etc. Salman Ahmad Khan contributed toward the manuscript drafting, english language edition, grammatical corrections and results discussion and analytical analysis. Dr. Mohammed Arifuddin, involved in the conceptualization and optimization of reaction condition, literature search and writing and drafting of the manuscript and Ms. Aram Rehman, Research scholar has contributed in the experimental work and analytical data collections.

Disclosure statement

All the authors declare that there are no conflicts of interest. The spectral data is got from SPARK ANALYTICAL, Hyderabad on payment basis.