Synthesis of New Spiropyrrolo[3,4-b]Pyridine Derivatives Employed Multicomponent Reactions

Abstract

In this research, novel derivatives of spiropyrrolo[3,4-b]pyridine derivatives were synthesized in high yields by using multicomponent reaction (MCR) of ninhydrin, ammonium acetate, ethyl 2,4-dioxo-4-arylbutanoates, primary amines, methyl propiolate, and triethyl amine (Et₃N) in aqueous media. The antioxidant activity of new synthesized spiropyrrolo[3,4-b]pyridine derivatives is due to having OH group which was evaluated by two procedures. This employed procedure for preparation of spiropyrrolo[3,4-b]pyridine derivatives conveys benefits including reaction with low time, products with high yields, and easy separation of products using an easy procedure.

Graphical Abstract

HIGHLIGHTS

• The spiropyrrolo[3,4-b]pyridine can be found in many molecules of biological or pharmaceutical interest.

• Multicomponent reactions (MCRs) are more interesting type of reaction due to mixing three or more reactants in one-pot and generating one product and economically useful and environmentally secure than to multi-step methods.

• Carrying out synthesis of organic compounds in water media is very interesting because of water is cheap solvent, more available with high amounts.

Keywords:

• Spiropyrrolo[3,4-b]pyridine derivatives
• multicomponent reaction
• primary amines
• 2,4-dioxo-4-arylbutanoate

Acknowledgments

The author sincerely would like to acknowledge the Islamic Azad University for its support.

Disclosure statement

No potential conflict of interest was reported by the authors