Synthesis and Insecticidal Activity of Novel Trifluoromethylbenzimidazole Linked N-Phenylamide Compounds

Abstract

A series of new 5-(trifluoromethyl)-benzo[d]imidazole linked N-phenylamide compounds was designed and synthesized using 1-chloro-2-nitro-4-(trifluoromethyl)benzene as raw material via five steps. Their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. The bioassay results indicated that some of them exhibited moderate insecticidal activity (>50% inhibition) against Mythimna separata and Nilaparvata lugens at 500 μg/mL.

Keywords:

• Carboxamide
• benzimidazole
• synthesis
• insecticidal activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was funded by the Natural Science Foundation of Department of Education of Anhui Province (No. 2022AH051961), and the Young Core Talents Domestic Visitor Foundation of the Higher Education Institutions of Anhui Province (No. gxgnfx2022063), and the Talent Start Foundation of Huangshan University (No. 2018xkjq018) and Zhejiang Provincial Natural Science Foundation of China (No. LTGN23C140002, LY19C140002, LY19B020009), and the Chemical Company for Research (KYY-HX-20210140, KYY-HX-20190720).