Multi-step Synthesis of Novel Pyrazole Derivatives as Anticancer Agents

Abstract

The attractiveness of pyrazole and its derivatives is increasing because of their numerous potential pharmacological applications. A novel series of pyrazole hybrid compounds (6A–6L) has been synthesized, and all the intermediates and the final products were characterized by 1H NMR, IR, and mass spectrometry. Pyrazole derivatives were screened for their anticancer activity against the NCI-60 cell lines, and grouped into nine different subpanels. In-vitro anticancer studies of the targeted compounds showed that the compounds 6C, 6D, 6F, 6I, and 6J showed potent anticancer activity against renal cancer, ovarian cancer, melanoma, and leukemia cancer.

Keywords:

• Pyrazole
• spectroscopy
• anticancer screening
• NCI-60 cell line

Acknowledgments

The authors are thankful to the Department of Chemistry, Saurashtra University, Rajkot for a facility of chemical and research lab. SHODH scheme for research fellowship. The authors are grateful to the CoE-NFDD for providing a facility for spectral data. Special thanks to the National Cancer Institute/National Institute of Health (NCI-NIH) in the United States for the anticancer testing of synthesized molecules.

Disclosure statement

No potential conflict of interest was reported by the author(s).