Abstract
In the present work, the antibacterial and antifungal properties of six new heterocyclic Schiff bases (HSb1, HSb2, HSb3, HSb4, HSb5, HSb6) were evaluated as potential bioactive compounds against the disease-causing pathogenic microorganisms (S.epidermidis, S.aureus, B.cereus RSKK863, E.aerogenes, P.aeroginosa sp., K. pneumonia, S. type H, P.vulgaris, E. coli and (C.albicans Y-1200-NIH). The well-diffusion-method was used to determine the antimicrobial activity. For this purpose, heterocyclic Schiff bases were synthesized by condensation reaction of aldehyde derivatives and thiosemicarbazide derivatives. Spectral analysis techniques (organic elemental analysis, FT-IR,1H-NMR, HRMS, SEM-EDX) were used to characterize the synthesized compounds. It was determined that all the newly synthesized heterocyclic Schiff bases exhibited sound, high or moderate inhibitory effects on the growth of selected different standard antibiotics.
Ethical approval
This article does not contain any studies with human participants or animals performed by any of the authors.
Authors’ contributions
D. NARTOP designed the experiments and contributed to the interpretation of the results. A. Zeynep MACİT carried out the experiments depending on synthesis. D. NARTOP and E. HASANOĞLU ÖZKAN performed visualization, formal analysis, writing-original draft, writing-review & editing, H.OGUTCU carried out the antimicrobial assessment. The each author contributed to the final manuscript and discussed the findings.
Disclosure statement
No potential conflict of interest was reported by the author(s).