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Abstract
An efficient, ultrasound assisted catalyst-free, green protocol has been developed for the synthesis of 1,2,3-triazolyl phenylhydrazone derivatives under environmentally benign condition. The antioxidant activity for all the synthesized derivatives were evaluated in vitro by using 1,1-diphenylpicrylhydrazyl (DPPH) radical scavenging method. The compounds 6a, 6e, 6f, and 6i were shows an excellent antioxidant activity than the standard drug butylated hydroxy toluene with IC50 values in the range 12.03 ± 0.11–14.07 ± 0.31 µg/mL. Molecular docking study was also performed to elaborate their possible interactions with Myeloperoxidase enzyme. Furthermore, in silico ADME properties for all the compounds were also studied.
Graphical Abstract
Acknowledgments
One of the author S. P. K. is grateful to Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, for the award of University Scholars Fellowship. Dr. Bapurao B. Shingate is grateful to Dr. Babasaheb Ambedkar Marathwada University, Aurangabad for a minor research project (Plan & Stat/RDC/2022-23/760-63). Authors are also thankful to the Head, Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431 004, Maharashtra, India, for providing laboratory facility.
Author’s contributions
SPK performed the experimental work, prepared the graphical abstract, and wrote the manuscript. TRD also contributed in manuscript writing as well as supporting information. JNS performed the biological activity. VMK carried out the molecular docking study. The research and manuscript writing were reviewed and monitored under the guidance of BBS.
Availability of data and materials
Not applicable.
Competing interests
The authors declare no competing interests.
Disclosure statement
The authors declare there is no conflict of interest.
Ethical approval
Not applicable.