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Abstract
Anthanthrene (dibenzo[def,mno]chrysene), a hexacyclic aromatic hydrocarbon lacking the structural element of a bay-region is found to be metabolized to 3-hydroxyanthanthrene (3-HA) and anthanthrene 3,6-quinone by rat liver microsomes. Two further metabolites of anthanthrene are are also derived as metabolites of 3-HA. 3-HA forms stable radicals in the presence of horseradish peroxidase and hydrogen peroxide as revealed by electron spin resonance spectroscopy. These radical species which are also formed spontaneously from 3-HA could be responsible for the genotoxic properties of anthanthrene.