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Numerical Heat Transfer, Part A: Applications
An International Journal of Computation and Methodology
Volume 46, 2004 - Issue 6
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Original Articles

NUMERICAL SIMULATION OF 3-D FREEZING AND HEATING PROBLEMS FOR COMBINED CRYOSURGERY AND HYPERTHERMIA THERAPY

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Pages 587-611 | Received 01 Jan 2004, Accepted 01 Apr 2004, Published online: 17 Aug 2010
 

Abstract

Recently, a new tumor ablation modality based on freezing immediately followed by a rapid and strong enough heating has been proved to be more effective and flexible than conventional cryosurgery. In this study, a numerical algorithm based on the effective heat capacity method is established to solve three-dimensional (3-D) phase-change problems of biological tissues subject to combined freezing and heating. The accuracy of the numerical code thus compiled is validated through comparisons of the calculation results with a 1-D exact solution for a semi-infinite region solidification problem. Using the present algorithm, comprehensive analysis is performed on the freezing/thawing behavior of biological tissues with tumors. For treatment of large tumors, where strong cooling/heating power is required, a single probe will not be able to address a sufficiently large volume. For this case, freezing/heating problems using a three-probe system are solved for illustration purposes. The present algorithm is expected to be a valuable treatment-planning tool for combined cryosurgery and hyperthermia therapy.

This work was partially supported by the National Natural Science Foundation of China under grants 50325622 and 50306027.

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