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Numerical Heat Transfer, Part A: Applications
An International Journal of Computation and Methodology
Volume 50, 2006 - Issue 9
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Original Articles

Optimal Temperature Distribution in a Three-Dimensional Triple-Layered Skin Structure Embedded with Artery and Vein Vasculature

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Pages 809-834 | Received 21 Dec 2005, Accepted 03 Feb 2006, Published online: 04 Dec 2006
 

Abstract

In recent years there has been interest in research related to hyperthermia combined with radiation and cytotoxic drugs to enhance the killing of tumors. When heating the tumor tissue, the crucial problem is keeping the temperature of the normal tissue surrounding the tumor below a certain threshold so as not to cause damage to the tissue. Hence, in order to control the process, it is important to obtain a temperature field of the entire treatment region. In this article, we develop a numerical method for obtaining an optimal temperature distribution in a triple-layered skin structure embedded with two countercurrent, multilevel blood vessels: artery and vein.

Acknowledgments

This research was supported by a Louisiana Tech University summer grant, no. 22-0001-99032.

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