Temperature Prediction for Tumor Hyperthermia with the Behavior of Thermal Wave

Abstract

In magnetic nanoparticle hyperthermia for cancer treatment, controlling the heat distribution and temperature elevations is an immense challenge in clinical applications. It is expected for treatment quality to understand the heat transport occurring in biological tissue. The non-Fourier thermal behavior in biological tissue has been experimentally observed. This work uses the thermal wave model to predict the temperature excess occurring in a two-layer concentric spherical tissue with the heat source of Gaussian distribution. The solutions to the hyperbolic bio-heat equation with the space-dependent source term in the spherical coordinate system are presented. The influences of relaxation time, blood perfusion rate, and heating strength on the thermal response in tumor and normal tissue are discussed.

Support for this work by the National Science Counsel under grant no. NSC 98-2212-E-269-018 is gratefully acknowledged.