Review of Analytical Methods for Identification and Determination of PHEs and Tricyclic Antidepressants

Abstract

A critical review of analytical methods for identification and determination of some phenothiazine derivatives and tricyclic antidepressants in a variety of materials is presented. The methods have been divided into five groups accordingly to the applied analytical techniques: spectrometric, chromatographic, immunoassay, electrochemical, and capillary electrophoretic. The review is based on a survey of chemical and toxicological literature covering the articles mainly from 2000 until now. A brief description of physicochemical properties of the compounds of interest has been also presented.

Keywords:

• PHEs
• tricyclic antidepressants
• identification and determination methods
• biological samples
• pharmaceutical preparations

Notes

^a Date have not been found.

^b Partition coefficient was determined versus octanol/buffer pH 7.4 (or pH 7.0), in the rest cases versus octanol/water.

^c The drugs are usually administered as hydrochlorides with some exceptions such as for example: perazine (dimalonate), levomepromazine (maleate) and thioridazine (mesilate).

^d Data from [3].

^e Date from [4].