A Critical Review of Screening Methods for the Detection of Chloramphenicol, Thiamphenicol, and Florfenicol Residues in Foodstuffs

Abstract

This article gives an extensive overview of the wide range of analytical procedures developed for the detection of amphenicol antibiotic residues (chloramphenicol, thiamphenicol, and florfenicol) in many different types of foodstuffs (milk, meat, eggs, honey, seafood). Screening methods such as microbial inhibition methods, antibody-based immunoassays using conventional and biosensor-based detection systems, and some methods based on alternative recognition systems are described. The relative advantages and disadvantages of these methods are discussed and compared. The current status and future trends and developments in the need for accurate and rapid detection of this group of antimicrobials are also discussed.

Keywords:

• amphenicols
• chloramphenicol
• thiamphenicol
• florfenicol
• residues
• immunoassay
• biosensors
• screening
• food

Notes

^aDecision limit (CCα).

^aPoly-TTCA/AuNPs/Den/CdS: poly 5, 2′:5′,2′′-tethiophene-3′-carboxyl acid/gold nanoparticle/dendrimer/cadmium sulfide nanoparticles.

^bSATUM/AuNPs/MSA: a self-assembled thiourea monolayer/gold nanoparticle mercaptosuccinic acid.

^aDetection range.

^bIC₅₀: inhibition concentration at 50%.

^aLimit of quantification.