Fluorescent Probes Used for Detection of Hydrogen Peroxide under Biological Conditions

ABSTRACT

Hydrogen peroxide is a well-established precursor of reactive oxygen and nitrogen species that are known to contribute to oxidative stress—the crucial factor responsible for the course of a wide range of phy-sicochemical processes as well as the genesis of various diseases, such as cancer and neurodegenerative disorders. Thus, the development of sensitive and selective methods for the detection and quantitative determination of hydrogen peroxide is of great importance in monitoring the in vivo production of that species and elucidating its biological functions. This review highlights the progress that has been made in the development of fluorescent and luminescent probes (excluding nanoparticles) employed to monitor hydrogen peroxide under biological conditions. Attention was focused on probes developed in the past 10 years.

KEYWORDS:

• Boronate probes
• detection of hydrogen peroxide
• fluorescent probes
• nonboronate probes
• reactive oxygen species

Funding

This work was supported by the Polish National Science Centre (NCN) under Grant No. 2012/07/B/ST5/00753.