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ABSTRACT
Fiber optic–based biosensors with surface plasmon resonance (SPR) technology are advanced label-free optical biosensing methods. They have brought tremendous progress in the sensing of various chemical and biological species. This review summarizes four sensing configurations (prism, grating, waveguide, and fiber optic) with two ways, attenuated total reflection (ATR) and diffraction, to excite the surface plasmons. Meanwhile, the designs of different probes (U-bent, tapered, and other probes) are also described. Finally, four major types of biosensors, immunosensor, DNA biosensor, enzyme biosensor, and living cell biosensor, are discussed in detail for their sensing principles and applications. Future prospects of fiber optic–based SPR sensor technology are discussed.
Acknowledgment
We also thank Jiantao Tan and Guanghui Niu for their assistance in the preparation of this article.
Funding
The authors acknowledge funding provided by the National Natural Science Foundation of China: Investigation of Fast Pathogen Detection Based on Novel Macroporous Chips Technology (no.21275105), National Recruitment Program of Global Experts (NRPGE), and the Hundred Talents Program of Sichuan Province (HTPSP), and the Startup Funding of Sichuan University for setting up the Research Center of Analytical Instrumentation.