Medicinal Importance, Coordination Chemistry with Selected Metals (Cu, Ag, Au) and Chemosensing of Thiourea Derivatives. A Review

Abstract

Thiourea and its derivatives are versatile compounds used in several fields of life ranging from medicinal to chemosensor applications. In this review article, generally used preparative methods of thiourea, its coordination compounds with selected metals (Cu, Ag, Au) for biological and medicinal applications and the potentials of thiourea derivatives in analytical chemistry as chemosensors have been discussed. The improved activities of these derivatives in the field of pharmaceutical chemistry can be achieved by coordination with a suitable metal ion. The two fields, selected coordination chemistry and chemosensing of thiourea derivatives are discussed. Since thiourea derivatives are biologically active therefore, their use as chemosensors can be useful to detect anions and cations in environmental and biological samples. The review contains 212 references.

Graphical Abstract

Keywords:

• Thiourea derivatives
• preparation
• Cu/Ag/Au coordination chemistry
• biological applications
• chemosensors

Acknowledgements

EK is grateful to HEC, Pakistan for financial support under NRPU grant No. 1488 and 7327. We are indebted to anonymous reviewers for their time and efforts being putted to improve this review article.

Conflict of interest

Authors declare no conflict of interest