Progress of Pretreatment and Analytical Methods of Proton Pump Inhibitors: An Update since 2010

Abstract

Proton pump inhibitors (PPIs) are the most commonly used medication for stomach secretion disorders. However, when it comes to safe, discreet pharmaceutical practice, widely recognized preparational and analytical method(s) for PPIs with sensitivity, selectivity, speed and high accuracy still remains underdeveloped. For this reason, this paper sets out to make a comprehensive review of the preparation and determination methods for PPIs based on multiple matrices since 2010. We have integrated newly-developed techniques (such as solid phase extraction, liquid phase micro-extraction, and solid phase micro-extraction) into conventional sample preparational methods. On the other hand, our analytical techniques include liquid chromatography, supercritical fluid chromatography, capillary electrophoresis, and employment of sensors. In addition, we have identified the pros and cons of each technique and have forecast their future developmental trends.

HIGHLIGHTS

• Development of preparational and analytical methods for PPIs has been documented.

• The pros and cons of different pretreatment techniques have been specifically identified with comparison.

• The evolution of different microextraction methods for PPIs has been presented.

• The future trends of pretreatment and analytical methods for PPIs have been discussed.

Graphical Abstract

Keywords:

• Analytical techniques
• drug safety
• overview
• proton pump inhibitors
• pretreatment

CRediT authorship contribution statement

De-mei Sun: Original Draft. Yuan Zhang: Writing –review & editing, Conceptualization. Yu Zhou: Supervision. Xue-song Feng: Conceptualization, Validation. Xin-yuan Zhang: Conceptualization, Validation.

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Funding

This work was supported by the Scientific Research Project of the Department of Education of Liaoning Province (ZF2019036).