Research Progress of SERS Sensors Based on Hydrogen Peroxide and Related Substances

Abstract

Hydrogen peroxide (H₂O₂) has an important role in living organisms, and its detection is of great importance in medical, chemical, and food safety applications. This review provides a comparison of different types of Surface-enhanced Raman scattering (SERS) sensors for H₂O₂ and related substances with respect to their detection limits, which are of interest due to high sensitivity compared to conventional sensors. According to the latest research report, this review focuses on the sensing mechanism of different sensors and summarizes the linear range, detection limits, and cellular applications of new SERS sensors, and discusses the limitations in vivo and future prospects of SERS technology for the detection of H₂O_2.

Keywords:

• Hydrogen peroxide (H₂O₂)
• intracellular sensors
• nanozyme
• surface-enhanced Raman scattering

Authors’ contributions

Ruan Shuyan: article writing; Liu Wenting: article collection; Wang Wenxi: literature classification and collation; Lu Yudong: resources.

Disclosure statement

We declare that we have no financial or personal relationships with other people or organizations.

Table 5. The detection of related substance.

Additional information

Funding

This review was supported by grants from Fujian Provincial Department of Science and Technology guiding Project (2020Y0019), Youth and Middle-aged Backbone Talents Training Project of Fujian Health Commission (2020GGA003), Industry-university Cooperation Project of Fujian Provincial Department of Science and Technology (2020N5006), Fushimei Agricultural and rural maker space (Minke xing (2019) No.2), Undergraduate Innovation and Entrepreneurship Training Program of Fujian Normal University (cxxl-2022247).