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Abstract
Saliva is one of the most critical human body fluids that can reflect the state of the human body. The detection of saliva is of great significance for disease diagnosis and health monitoring. Microfluidics, characterized by microscale size and high integration, is an ideal platform for the development of rapid and low-cost disease diagnostic techniques and devices. Microfluidic-based saliva testing methods have aroused considerable interest due to the increasing need for noninvasive testing and frequent or long-term testing. This review briefly described the significance of saliva analysis and generally classified the targets in saliva detection into pathogenic microorganisms, inorganic substances, and organic substances. By using this classification as a benchmark, the state-of-the-art research results on microfluidic detection of various substances in saliva were summarized. This work also put forward the challenges and future development directions of microfluidic detection methods for saliva.
Graphical Abstract
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Disclosure statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Data availability statement
No data was used for the research described in the article.
Author contributions
X.L., XT.S. and HZ.Y. conceptualized the idea of the review. X.L. wrote initial drafts of the manuscript. XY.Z., XJ.L., YX.W. and TL.W. contributed to data collection and graph making. S.L. contributed to writing and manuscript improvement. All authors contributed to writing and reviewing the manuscript and gave approval to the final version of the manuscript.