Advances in Fluorescent Nanosensors for Detection of Vitamin B₁₂

Abstract

Vitamin B₁₂ plays a significant role in maintaining human health. Deficiency or excess intake of vitamin B₁₂ may cause some diseases. Therefore, it is significant to fabricate sensors for sensitive assay of vitamin B₁₂. In the past few years, a variety of nanomaterials have been developed for the fluorescence detection of vitamin B₁₂ in tablets, injection, human serum and food. In the review, the assay mechanisms of fluorescent nanomaterials for sensing vitamin B₁₂ were first briefly discussed. And the progress of various nanomaterials for fluorescence detection of vitamin B₁₂ were systematically summarized. Furthermore, the sensing performance of fluorescent nanosensors was compared with fluorescent probes. Lastly, the challenges and perspectives about the topic were presented.

Keywords:

• Nanomaterials
• fluorescent assay
• vitamin B₁₂
• research advances

CRediT authorship contribution statement

Yongming Guo: Conceptualization, Resources, Funding acquisition, Project administration, Writing-original draft, Writing-review & editing. Yijin Li: Writing-original draft. Yubin Xiang: Funding acquisition, Writing-review & editing.

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Data availability statement

The authors are unable or have chosen not to specify which data has been used.

Additional information

Funding

The work was financially supported by College Student Innovation Training Program of Reading Academy of Nanjing University of Information Science and Technology, the National Natural Science Foundation of China (No. 22205114) and the Natural Science Foundation of Jiangsu Province (No. BK20190776).