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Critical Reviews in Clinical Laboratory Sciences Volume 55, 2018 - Issue 1
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Review Article

Cell-free DNA as a biomarker in stroke: Current status, problems and perspectives

Kristina V. GlebovaLaboratory of Molecular Biology, Federal State Budgetary Institution “Research Centre for Medical Genetics”, Moscow, Russia; Correspondence[email protected]
,
Natalya N. VeikoLaboratory of Molecular Biology, Federal State Budgetary Institution “Research Centre for Medical Genetics”, Moscow, Russia;
,
Aleksey A. NikonovDepartment of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, Moscow, Russia
,
Lev N. PorokhovnikLaboratory of Molecular Biology, Federal State Budgetary Institution “Research Centre for Medical Genetics”, Moscow, Russia;
&
Svetlana V. KostuykLaboratory of Molecular Biology, Federal State Budgetary Institution “Research Centre for Medical Genetics”, Moscow, Russia;
Pages 55-70 | Received 24 May 2017, Accepted 18 Dec 2017, Published online: 05 Jan 2018
 
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Abstract

There is currently no proposed stroke biomarker with consistent application in clinical practice. A number of studies have examined cell-free DNA (cfDNA), which circulates in biological fluids during stroke, as a potential biomarker of this disease. The data available suggest that dynamically-determined levels of blood cfDNA may provide new prognostic information for assessment of stroke severity and outcome. However, such an approach has its own difficulties and limitations. This review covers the potential role of cfDNA as a biomarker in stroke, and includes evidence from both animal models and clinical studies, protocols used to analyze cfDNA, and hypotheses on the origin of cfDNA.

Disclosure statement

No potential conflict of interest was reported by the authors.

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