Tumor Microenvironment as a New Target for Tumor Immunotherapy of Polysaccharides

Abstract

Many researches show that polysaccharides derived from fungi and plants have strong pharmacological activities such as enhancing the organism immune and anti-tumor function, and have few toxic and side effects. So the polysaccharides show a wide application prospect in the prevention and therapy of tumor. The tumor microenvironment consists of tumor cells and tumor cells' surrounding environment. The tumor microenvironment not only plays a key role in the development of tumor, but also is a potential treasure for searching new ways to treat tumor. In this review, we summarized polysaccharides' regulation effects on tumor microenvironment progression and tried to give a new theoretical basis for the exploitation of polysaccharides with anti-tumor activity.

Keywords:

• Polysaccharide
• tumor microenvironment
• immunological therapy

Funding

The financial support from the Key Program of National Natural Science Foundation of China (No: 31130041) and Research Program of State Key Laboratory of Food Science and Technology (SKLF-ZZA-201301), is gratefully acknowledged.