Dietary compounds as modulators of metals and metalloids toxicity

ABSTRACT

A large part of the population is exposed to metals and metalloids through the diet. Most of the in vivo studies on its toxicokinetics and toxicity are conducted by means of exposure through drinking water or by intragastric or intraperitoneal administration of aqueous standards, and therefore they do not consider the effect of the food matrix on the exposure. Numerous studies show that some components of the diet can modulate the toxicity of these food contaminants, reducing their effect on a systemic level. Part of this protective role may be due to a reduction of intestinal absorption and subsequent tissue accumulation of the toxic element, although it may also be a consequence of their ability to counteract the toxicity directly by their antioxidant and/or anti-inflammatory activity, among other factors. The present review provides a compilation of existing information about the effect that certain components of the diet have on the toxicokinetics and toxicity of the metals and metalloids of greatest toxicological importance that are present in food (arsenic, cadmium, lead, and mercury), and of their most toxic chemical species.

KEYWORDS:

• Arsenic
• mercury
• cadmium
• lead
• diet
• toxicokinetics
• toxicity

Funding

This work was supported by the Spanish Ministry of Economy and Competitiveness (AGL2012-33461), for which the authors are deeply indebted. Carlos Jadán-Piedra received a Personnel Training Grant from SENESCYT (Ecuadorian Ministry of Higher Education, Science, Technology and Innovation) and Gabriela de Matuoka e Chiocchetti, a fellowship from Brazilian Government (CAPES-proceso BEX1086/14-6).