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Critical Reviews in Food Science and Nutrition Volume 59, 2019 - Issue 3
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Iron influences on the Gut-Brain axis and development of type 2 diabetes

José Manuel Fernández RealUniversity Hospital of Girona ‘Dr JosepTrueta’, Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona IdibGi;CIBER Fisiopatología de la Obesidad y Nutrición, Girona, SpainCorrespondence[email protected]
, M.D., Ph.D.,
José Maria Moreno-NavarreteUniversity Hospital of Girona ‘Dr JosepTrueta’, Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona IdibGi;CIBER Fisiopatología de la Obesidad y Nutrición, Girona, Spain
&
Melania MancoResearch Area for multifactorial diseases, Bambino Gesù Children's Hospital and Research Institute, Research Unit for Multifactorial Disease, Rome, Italy
, M.D., Ph.D.
Pages 443-449 | Published online: 17 Oct 2017
 
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ABSTRACT

Background: Microbiota/neuroendocrine interactions with health and disease are increasingly recognized. Main Body: Aging is associated with progressive iron storage and development of type 2 diabetes, which impacts on brain microstructure and function, mainly in obese subjects. Iron status is also mutually influencing the composition of the gut microbiota, which in turn may affect cognition through the gut-brain axis. Short Conclusion: In this article we update the possible role of iron in all these interactions.

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