The impact of essential oils on antibiotic use in animal production regarding antimicrobial resistance – a review

Abstract

Population growth directly affects the global food supply, demanding a higher production efficiency without farmland expansion – in view of limited land resources and biodiversity loss worldwide. In such scenario, intensive agriculture practices have been widely used. A commonly applied method to maximize yield in animal production is the use of subtherapeutic doses of antibiotics as growth promoters. Because of the strong antibiotic selection pressure generated, the intense use of antibiotic growth promoters (AGP) has been associated to the rise of antimicrobial resistance (AMR). Also, cross-resistance can occur, leading to the emergence of multidrug-resistant pathogens and limiting treatment options in both human and animal health. Thereon, alternatives have been studied to replace AGP in animal production. Among such alternatives, essential oils and essential oil components (EOC) stand out positively from others due to, besides antimicrobial effectiveness, improving zootechnical indexes and modulating genes involved in resistance mechanisms. This review summarizes recent studies in essential oils and EOC for zoonotic bacteria control, providing detailed information about the molecular-level effects of their use in regard to AMR, and identifying important gaps to be filled within the animal production area.

Keywords:

• Antimicrobial cross-resistance
• essential oil components
• foodborne pathogens
• animal feed safety
• cinnamaldehyde
• carvacrol

Disclosure statement

The authors declare no conflicts of interest.

Additional information

Funding

National Council for Scientific and Technological Development, Brazil, process CNPq 142196/2019-3; Coordination for the Improvement of Higher Education Personnel, Brazil, financial code CAPES 001; Pontifical Catholic University of Paraná, Brazil.