The promising biological role of postbiotics derived from probiotic Lactobacillus species in reproductive health

Abstract

Recent investigations have meaningfully developed our knowledge of the features of the reproductive microbiome/metabolome profile and their relations with host responses to offer an optimal milieu for the development of the embryo during the peri-implantation period and throughout pregnancy. In this context, the establishment of homeostatic circumstances in the Female Reproductive Tract (FRT), in various physiological periods, is a significant challenge, which appears the application of postbiotics can facilitate the achievement of this goal. So, currently, scientific literature confirms that postbiotics due to their antimicrobial, antiviral, and immunomodulatory properties can be considered as a novel biotherapeutic approach. Future investigation in this field will shed more translational mechanistic understanding of the interaction of the postbiotics derived from vaginal Lactobacilli with females' health and reproduction.

Keywords:

• Postbiotic
• probiotic Lactobacillus
• therapeutic activity
• vaginal microbiome
• reproductive health

Acknowledgements

The authors would like to express their thanks to the Research Vice-Chancellor of Tabriz University of Medical Sciences for the financial support of this study.

Declaration of interest

The authors declare that they have no conflicts of interest.

Additional information

Funding

This study was funded by the Vice-Chancellor for Research of Tabriz University of Medical Sciences, Tabriz, Iran with reference number 64644.