Acetylated polysaccharides: Synthesis, physicochemical properties, bioactivities, and food applications

Abstract

Polysaccharides are biomacromolecular widely applied in the food industry, as gelling agents, thickeners and health supplements. As hydrophobic groups, acetyls provide amphiphilicity to polysaccharides with numerous hydroxyl groups, which greatly expand the presence of polysaccharides in organic organisms and various chemical environments. Acetylation could result in diverseness and promotion of the structure of polysaccharides, which improve the physicochemical properties and biological activities. High efficient and environmentally friendly access to acetylated derivatives of different polysaccharides is being explored. This review discusses and summarizes acetylated polysaccharides in terms of synthetic methods, physicochemical properties and biological activities and emphasizes the structure-effect relationships introduced by acetyl groups to reveal the potential mechanism of acetylated polysaccharides. Acetyls with different contents and substitution sites could change the molecular weight, monosaccharide composition and spatial architecture of polysaccharides, resulting in differences among properties such as water solubility, emulsification and crystallinity. Coupled with acetyls, polysaccharides have increased antioxidant, immunomodulatory, antitumor, and pro-prebiotic capacities. In addition, their possible applications have also been discussed in green food materials, bioactive ingredient carriers and functional food products, indicating that acetylated polysaccharides hold a clear vision in food health and industrial development.

Graphical Abstract

Highlights

1. Different catalysts and reagents could be chosen for acetylated polysaccharides preparation.

2. Changes in structure properties of acetyl groups can affect physical and biological activities.

3. Acetylated polysaccharides possess a lot of improved biological activities.

4. Acetylated polysaccharides have great potential in food, pharmaceutical and biomaterial areas.

Keywords:

• Acetylated polysaccharide
• modification
• property
• bioactivity
• application

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This work is financially supported by The National Youth Talent Support Program of China (2019).