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Critical Reviews in Microbiology Volume 32, 2006 - Issue 2
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Research Article

IdeR in Mycobacteria: From Target Recognition to Physiological Function

Sarita Ranjan Computational & Functional Genomics Group, Sun Centre of Excellence in Medical Bioinformatics, Centre for DNA Fingerprinting and Diagnostics, EMBnet India Node, Hyderabad, 500076, India
,
Sailu Yellaboina Computational & Functional Genomics Group, Sun Centre of Excellence in Medical Bioinformatics, Centre for DNA Fingerprinting and Diagnostics, EMBnet India Node, Hyderabad, 500076, India
&
Akash Ranjan Computational & Functional Genomics Group, Sun Centre of Excellence in Medical Bioinformatics, Centre for DNA Fingerprinting and Diagnostics, EMBnet India Node, Hyderabad, 500076, India
Pages 69-75 | Received 04 Jan 2006, Accepted 20 Jan 2006, Published online: 11 Oct 2008
 
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Abstract

In mycobacteria, iron dependent transcription regulator (IdeR) regulates transcription of genes in response to iron levels. The IdeR regulated genes have been investigated mostly in M. tuberculosis, M. smegmatis, and in few of the other related species. Recent advances in crystal structure solution and computational as well as experimental identification of IdeR targets has provided insight into IdeR structure and function. Here in this review we take stock of current state of knowledge on IdeR and its targets to understand the underlying design of the IdeR regulon and its role in mycobacterial physiology.

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