miRNAs in enterovirus infection

Abstract

During the last years, it has become evident that miRNAs are important players in almost all physiological and pathological processes, including viral infections. Enterovirus infections range from mild to severe acute infections concerning several organ systems and are also associated with chronic diseases. In this review, we summarize the findings on the impact of acute and persistent enterovirus infection on the expression of cellular miRNAs. Furthermore, the currently available data on the regulation of cellular or viral targets by the dysregulated miRNAs are reviewed. Finally, a translational perspective, namely the use of miRNAs as biomarkers of enterovirus infection and as antiviral strategy is discussed.

Keywords:

• MicroRNA
• coxsackievirus
• persistent infection
• acute infection
• enterovirus

Acknowledgements

The authors thank Delphine Caloone, the team of Laboratoire de Virologie EA3610 and all their collaborators.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Ministère de l’Education Nationale, de l’Enseignement Supérieur et de la Recherche, Université Lille 2 (Equipe d’accueil 3610), and Centre Hospitalier Régional et Universitaire de Lille.